Indiana (/ɪndiˈænə/) is a US state, admitted to the United States as the 19th on December 11, 1816. It is located in the midwestern and Great Lakes regions of North America. Indiana is the 38th largest by area and the 15th most populous of the 50 United States. Indiana is the least extensive state in the continental US west of the Appalachian Mountains. Its capital and largest city is Indianapolis, the second largest of any state capital and largest state capital east of the Mississippi River.