The first Jews in Derazhnia are reported in stories within Shivhei haBesht (stories about the Baal Shem Tov) that probably date from about 1750. The well-preserved Jewish Cemetery has burials from at least the late 18th century and maybe earlier. Derazhnia passed into Russian hands during the second partition of Poland in 1792. Starting in the 1840s, special Jewish agricultural colonies were granted close to Derazhnia. The largest and most prosperous was Staro Zakrevsky Meidan, founded 1844. It continued until it was turned into a kolkhoz Staro Meidan by the Soviets in 1928.