Sarandí Grande is a city in the north of the Florida Department of central Uruguay. It is located on the intersection of Route 5 with Route 42, about 140 kilometres (87 mi) from Montevideo, 43 kilometres (27 mi) north-northwest of Florida, the capital city of the department, and 43 kilometres (27 mi) south-southeast of Durazno, the capital city of the Durazno Department.